Pulmonary fibrosis and respiratory sequelae in patients recovered from SARS-CoV-2 infection [Fibrosis pulmonar y secuelas respiratorias en pacientes recuperados de infección por SARS-CoV-2]
DOI:
https://doi.org/10.62574/ebzc3x18Keywords:
COVID-19, pulmonary fibrosis, post-acute COVID-19 syndromeAbstract
Objective: To identify pulmonary sequelae and complications following COVID-19 disease. Method: Descriptive qualitative research with bibliographic search in databases such as Medline, PubMed, SciELO, WHO using descriptors related to post-COVID pulmonary sequelae. Forty scientific articles were reviewed, of which 25 met inclusion criteria and 18 were used for writing. Results: The most frequent pulmonary sequelae included pulmonary fibrosis, pulmonary embolism, pulmonary hypertension and vascular damage. Patients presented abnormal respiratory function, impaired exercise capacity, reduced carbon monoxide diffusion capacity and persistent inflammation of respiratory tissue. High rates of hospital readmission for pneumonia and respiratory diseases were observed. Conclusions: Persistent post-COVID syndrome generates multiple pulmonary complications that require multidisciplinary follow-up and long-term specialized management.
Downloads
References
Tanni SE, Fabro AT, de Albuquerque A, et al. Pulmonary fibrosis secondary to COVID-19: a narrative review. Expert Rev Respir Med. 2021;15(6):791–803. doi:10.1080/17476348.2021.1916472
McDonald LT. Healing after COVID-19: are survivors at risk for pulmonary fibrosis? Am J Physiol Lung Cell Mol Physiol. 2021;320(2):L257–L265.
Montani D, Savale L, Noël N, et al. Post-acute COVID-19 syndrome. Eur Respir Rev. 2022;31(163):210185.
Williams Z, Hull J. Respiratory complications following COVID-19 in athletic populations: a narrative review. Scand J Med Sci Sports. 2022;32(1):5–14. doi:10.1111/sms.14275
Ambardar SR, Hightower SL, Huprikar NA, et al. Post-COVID-19 pulmonary fibrosis: novel sequelae of the current pandemic. J Clin Med. 2021;10(11):2452.
Mostafa RM, Ibrahim IM. Post-COVID-19 pneumonia lung fibrosis: a worrisome sequelae in surviving patients. Egypt J Radiol Nucl Med. 2021;52:101.
Sanyaolu A, Marinkovic A, Prakash S, et al. Post-acute sequelae in COVID-19 survivors: an overview. SN Compr Clin Med. 2022;4(1):91.
Fraser E. Long term respiratory complications of COVID-19. BMJ. 2020;370:m3001.
Platto S, Xue T, Carafoli E. COVID-19: an announced pandemic. Cell Death Dis. 2020;11:799.
Ruggiero V, Aquino RP, Del Gaudio P, et al. Post-COVID syndrome: research progress in the treatment of pulmonary sequelae after COVID-19 infection. Pharmaceutics. 2022;14(6):1135.
Sarfraz Z, Sarfraz A, Barrios A, et al. Cardio-pulmonary sequelae in recovered COVID-19 patients: considerations for primary care. J Prim Care Community Health. 2021;12:21501327211023726. doi:10.1177/21501327211023726
Ahmed O, Kakamad FH, Hama B, et al. Post COVID-19 pulmonary complications; a single center experience. Ann Med Surg (Lond). 2021;72:103052.
Jahdhami I, Alnaamani K, Al Mawali A. Respiratory complications after COVID-19. Oman Med J. 2022;37(4):e352. doi:10.5001/omj.2022.52
Yang K, Wen G, Wang J, et al. Complication and sequelae of COVID-19: what should we pay attention to in the post-epidemic era. Front Immunol. 2021;12:711741.
Shi J, Danesh-Meyer HV. A review of neuro-ophthalmic sequelae following COVID-19 infection and vaccination. Front Cell Infect Microbiol. 2024;14:1345683. Published 2024 Jan 17. doi:10.3389/fcimb.2024.1345683
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Juan Esteban Lalama-Rueda, Daniela Abigail Cobo-Álvarez (Autor/a)

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
CC BY-NC-SA : Esta licencia permite a los reutilizadores distribuir, remezclar, adaptar y construir sobre el material en cualquier medio o formato solo con fines no comerciales, y solo siempre y cuando se dé la atribución al creador. Si remezcla, adapta o construye sobre el material, debe licenciar el material modificado bajo términos idénticos.




