Pharmacological treatment of complicated pneumonia in pediatric patients assisted in intensive care units [Tratamiento farmacológico de la neumonía complicada en pacientes pediátricos asistidos en unidades de cuidados intensivos]
DOI:
https://doi.org/10.62574/n8ea1s15Keywords:
pneumonia, pediatric, treatmentAbstract
Objective: To determine the efficacy of pharmacological treatment with systemic corticosteroids as adjuvant therapy in complicated pneumonia in pediatric patients assisted in intensive care units. Method: Systematic review of cohort studies published between 2018-2023 in NCBI, PubMed and New England Journal databases. Pediatric patients with complicated pneumonia treated with antibiotic therapy and corticosteroids versus antibiotic monotherapy were analyzed. Results: Combined therapy demonstrated significant reduction in fever duration, hospital stay and recovery time. At Shanghai Hospital, patients with corticosteroids had shorter hospitalization time and better clinical radiological evolution. Ampicillin monotherapy was used in 69.5% of cases as first-line treatment. Conclusions: Administration of systemic corticosteroids as adjuvant therapy significantly improves clinical outcomes in complicated pediatric pneumonia, reducing morbidity without significant side effects.
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References
Martin-Loeches I, Torres A. Corticosteroids for cap, influenza and covid-19: When, how and benefits or harm? Eur Respir Rev. 2021;30(159):1-9.
Liu J, He R, Zhang X, Zhao F, Liu L, Wang H, et al. Clinical features and "early" corticosteroid treatment outcome of pediatric mycoplasma pneumoniae pneumonia. Front Cell Infect Microbiol. 2023;13:1-10.
Zar HJ, Moore DP, Andronikou S, Argent AC, Avenant T, Cohen C, et al. Diagnosis and management of community-acquired pneumonia in children: South African thoracic society guidelines. Afr J Thorac Crit Care Med. 2020;26(3):95-116.
Masarweh K, Gur M, Toukan Y, Bar-Yoseph R, Kassis I, Gut G, et al. Factors associated with complicated pneumonia in children. Pediatr Pulmonol. 2021;56(8):2700-6.
Alemayheu G, Lee CSJ, Erdman LK, Wong J, Rutherford C, Smieja M, et al. Children hospitalized with community-acquired pneumonia complicated by effusion: a single-centre retrospective cohort study. BMC Pediatr. 2023;23(1):1-6.
Torres A, Cilloniz C, Niederman MS, Menéndez R, Chalmers JD, Wunderink RG, et al. Pneumonia. Nat Rev Dis Primers. 2021;7(1):1-16.
Nguyen PTK, Robinson PD, Fitzgerald DA, Marais BJ. The dilemma of improving rational antibiotic use in pediatric community-acquired pneumonia. Front Pediatr. 2023;11:1-9.
Korppi M. Antibiotic therapy in children with community-acquired pneumonia. Acta Paediatr. 2021;110(12):3246-50.
Chen Y, Li L, Wang C, Zhang Y, Zhou Y. Necrotizing Pneumonia in Children: Early Recognition and Management. J Clin Med. 2023;12(6):1-15.
Pokhrel B, Koirala T, Gautam D, Kumar A, Camara BS, Saw S, et al. Antibiotic use and treatment outcomes among children with community-acquired pneumonia admitted to a tertiary care public hospital in nepal. Trop Med Infect Dis. 2021;6(2):1-11.
Stern A, Skalsky K, Avni T, Carrara E, Leibovici L, Paul M. Corticosteroids for pneumonia. Cochrane Database Syst Rev. 2017;2017(12):1-89.
An J, Baek KS, Lee S. The effects of systemic corticosteroid on pediatric community-acquired pneumonia: comprehensive review. Life Cycle. 2022;2:1-7.
Llerena DM. Resultado clínico y costo económico directo del tratamiento de la neumonia adquirida en la comunidad en niños mayores de 28 dias y menores de 5 años en el Hospital General San Francisco y Hospital General Enrique Garces, en el periodo Enero - Diciembre. Pontificia Universidad Católica del Ecuador. 2019;63-75.
Zhang L, Wang L, Xu S, Li H, Chu C, Liu Q, et al. Low-Dose Corticosteroid Treatment in Children With Mycoplasma pneumoniae Pneumonia: A Retrospective Cohort Study. Front Pediatr. 2020;8:1-10.
Saleem N, Kulkarni A, Snow TAC, Ambler G, Singer M, Arulkumaran N. Effect of Corticosteroids on Mortality and Clinical Cure in Community-Acquired Pneumonia: A Systematic Review, Meta-analysis, and Meta-regression of Randomized Control Trials. Chest. 2023;163(3):484-97.
Salluh JIF, Póvoa P, Soares M, Castro-Faria-Neto HC, Bozza FA, Bozza PT. The role of corticosteroids in severe community-acquired pneumonia: A systematic review. Crit Care. 2008;12(3):1-7.
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