Osteogenic distraction in patients with atrophied jawbones. Systematic review [Distracción osteogénica en pacientes con maxilares atrofiados. Revisión sistemática]
DOI:
https://doi.org/10.62574/1yezpp07Keywords:
open bite, malocclusion, malocclusion, angle class IIAbstract
Objective: to analyse osteogenic distraction in patients with atrophied jaws. Method: systematic review of a population of 19 scientific articles. Results and Conclusion: osteogenic distraction represents a promising technique for the reconstruction of atrophied jaws, supported by solid biological foundations and technological advances. Current evidence demonstrates the critical importance of Wnt/β-catenin and Hedgehog signalling pathways in the regulation of osteogenesis, as well as the interdependence between angiogenesis and bone formation for optimal results.
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Kerbrat JB, Miskowiak C, Trost O, Kerbrat A. Osteogenic distraction to treat solitary median maxillary central incisor (SMMCI) syndrome: a case report. Int J Oral Maxillofac Surg. 2022;51(11):1469-1472. doi:10.1016/j.ijom.2022.03.006
Shen J, Sun Y, Liu X, et al. EGFL6 regulates angiogenesis and osteogenesis in distraction osteogenesis via Wnt/β-catenin signaling. Stem Cell Res Ther. 2021;12(1):415. Published 2021 Jul 22. doi:10.1186/s13287-021-02487-3
Jin M, An Y, Wang Z, et al. Distraction force promotes the osteogenic differentiation of Gli1+ cells in facial sutures via primary cilia-mediated Hedgehog signaling pathway. Stem Cell Res Ther. 2024;15(1):198. Published 2024 Jul 6. doi:10.1186/s13287-024-03811-3
Tevlin R, Griffin M, Chen K, et al. Denervation during mandibular distraction osteogenesis results in impaired bone formation. Sci Rep. 2023;13(1):2097. Published 2023 Feb 6. doi:10.1038/s41598-023-27921-9
Wu XM, Mai YX, Wen YF, et al. Silence of HOTAIR promotes osteogenic differentiation and accelerates distraction osteogenesis by mediating FTO ubiquitination. J Orthop Translat. 2025;50:248-256. Published 2025 Jan 20. doi:10.1016/j.jot.2024.12.001
Wang F, Qian H, Kong L, et al. Accelerated Bone Regeneration by Astragaloside IV through Stimulating the Coupling of Osteogenesis and Angiogenesis. Int J Biol Sci. 2021;17(7):1821-1836. Published 2021 Apr 24. doi:10.7150/ijbs.57681
Altaweel AA, Baiomy AABA, Shoshan HS, et al. Evaluation of osteogenic potential of Cissus quadrangularis on mandibular alveolar ridge distraction. BMC Oral Health. 2021;21(1):491. Published 2021 Oct 4. doi:10.1186/s12903-021-01847-y
Nixon-Martins A, Conduto D, Gomes AR, et al. Soft-tissue, non-osteogenic distraction of the mandible and lower face in bilateral hemifacial microsomia-technical report. J Craniomaxillofac Surg. 2024;52(4):469-471. doi:10.1016/j.jcms.2024.01.023
Ye J, Wang J, Zhao J, et al. RhoA/ROCK-TAZ Axis regulates bone formation within calvarial trans-sutural distraction osteogenesis. Cell Signal. 2024;121:111300. doi:10.1016/j.cellsig.2024.111300
Weill P, Dubois G, Preudhomme R, Rouch P, Veyssiere A, Benateau H. Optimisation du transfert de planification de la distraction ostéogénique mandibulaire par dispositif externe sur mesure [Improving the accuracy of the preoperative planning of mandibular osteogenic distraction by an external custom-made device]. Ann Chir Plast Esthet. 2023;68(2):113-122. doi:10.1016/j.anplas.2022.12.005
Jiang WD, Zhu PQ, Zhang T, et al. PRRX1+MSCs Enhance Mandibular Regeneration during Distraction Osteogenesis. J Dent Res. 2023;102(9):1058-1068. doi:10.1177/00220345231176522
Pech Gourg G, Serratrice N, Gallucci A, Scavarda D. Upward vectors for osteogenic distraction treatment in secondary chronic intracranial hypertension in children undergoing scaphocephaly surgery: 2 cases reported. Childs Nerv Syst. 2020;36(6):1325-1330. doi:10.1007/s00381-019-04491-8
Li K, Liu L, Zhang J, Liao C, Hu J, Song J. TP508 Promotes Bone Regeneration on Distraction Osteogenesis via the Activation of Wnt/β-catenin Signaling Pathway. Curr Pharm Biotechnol. 2025;26(3):402-410. doi:10.2174/0113892010289575240306033011
Liang W, Zhao E, Li G, Bi H, Zhao Z. Suture Cells in a Mechanical Stretching Niche: Critical Contributors to Trans-sutural Distraction Osteogenesis. Calcif Tissue Int. 2022;110(3):285-293. doi:10.1007/s00223-021-00927-z
Zhang L, Peng Y, Guo T, Fang W, Li Z, Yang X. Uniaxial static strain enhances osteogenic and angiogenic potential under hypoxic conditions in distraction osteogenesis. J Orthop Surg Res. 2024;19(1):711. Published 2024 Nov 1. doi:10.1186/s13018-024-05212-x
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